CJC-1295 with DAC

CJC-1295 With DAC 5 mg

Description

CJC-1295 With DAC is a long-acting synthetic analogue of Growth Hormone-Releasing Hormone (GHRH), developed for scientific research applications. It incorporates a Drug Affinity Complex (DAC), enabling reversible binding to serum albumin and significantly extending its circulation time compared to native GHRH.

Due to its prolonged half-life and enhanced stability, CJC-1295 With DAC has become one of the most extensively studied GHRH analogues in research involving endocrine signaling, pharmacokinetics, and growth hormone physiology.

Studies have demonstrated that albumin binding can extend biological activity from minutes to several days in experimental models, making it a valuable tool for long-term investigations.

Research Applications

Growth Hormone-Releasing Hormone (GHRH) research

Long-acting peptide investigations

Albumin-binding pharmacokinetic studies

Comparative studies of GHRH analogues

Growth hormone axis signaling research

Endocrine and metabolic pathway investigations

Plasma stability and half-life studies

Experimental pharmacology and molecular biology research

This product is supplied as lyophilized powder for research purposes only.

Scientific Background

Growth Hormone-Releasing Hormone (GHRH) is a naturally occurring hypothalamic peptide responsible for stimulating growth hormone secretion through activation of the GHRH receptor, a Class B G protein-coupled receptor expressed on pituitary somatotroph cells.

Native GHRH exhibits a very short plasma half-life due to rapid degradation by enzymes such as dipeptidyl peptidase IV (DPP-IV) and other proteolytic mechanisms, limiting its usefulness for prolonged experimental studies.

CJC-1295 With DAC was engineered from the biologically active GHRH(1–29) fragment and incorporates several amino acid substitutions that improve resistance to enzymatic degradation. Additionally, the peptide contains a Drug Affinity Complex (DAC) based on a maleimidopropionic acid (MPA) group that covalently binds to the free cysteine-34 residue of circulating serum albumin.

This albumin-binding mechanism dramatically prolongs systemic exposure and enables sustained activation of GHRH signaling pathways in experimental models.

Key Features

Synthetic GHRH analogue

Drug Affinity Complex (DAC) technology

Extended plasma half-life

Improved metabolic stability

Lyophilized powder

≥99% purity

Manufactured for laboratory research only

Specifications

Product Name: CJC-1295 With DAC

Content: 5 mg

Format: Lyophilized Powder

Purity: ≥99%

Storage: Store refrigerated at 2–8°C. Protect from light and moisture.

Reconstitution: Reconstitute using bacteriostatic water or sterile water intended for laboratory research.

Research Grade: Laboratory Research Material

Disclaimer

For Research Use Only (RUO). This product is intended exclusively for laboratory and scientific research. It is not intended for human consumption, veterinary use, diagnosis, treatment, or prevention of any disease.