{"product_id":"cjc-1295-with-dac-5mg","title":"CJC-1295 with DAC","description":"\u003cp\u003eCJC-1295 With DAC 5 mg\u003c\/p\u003e\n\u003cp\u003eDescription\u003c\/p\u003e\n\u003cp\u003eCJC-1295 With DAC is a long-acting synthetic analogue of Growth Hormone-Releasing Hormone (GHRH), developed for scientific research applications. It incorporates a Drug Affinity Complex (DAC), enabling reversible binding to serum albumin and significantly extending its circulation time compared to native GHRH.\u003c\/p\u003e\n\u003cp\u003eDue to its prolonged half-life and enhanced stability, CJC-1295 With DAC has become one of the most extensively studied GHRH analogues in research involving endocrine signaling, pharmacokinetics, and growth hormone physiology.\u003c\/p\u003e\n\u003cp\u003eStudies have demonstrated that albumin binding can extend biological activity from minutes to several days in experimental models, making it a valuable tool for long-term investigations.\u003c\/p\u003e\n\u003cp\u003eResearch Applications\u003c\/p\u003e\n\u003cp\u003eGrowth Hormone-Releasing Hormone (GHRH) research\u003c\/p\u003e\n\u003cp\u003eLong-acting peptide investigations\u003c\/p\u003e\n\u003cp\u003eAlbumin-binding pharmacokinetic studies\u003c\/p\u003e\n\u003cp\u003eComparative studies of GHRH analogues\u003c\/p\u003e\n\u003cp\u003eGrowth hormone axis signaling research\u003c\/p\u003e\n\u003cp\u003eEndocrine and metabolic pathway investigations\u003c\/p\u003e\n\u003cp\u003ePlasma stability and half-life studies\u003c\/p\u003e\n\u003cp\u003eExperimental pharmacology and molecular biology research\u003c\/p\u003e\n\u003cp\u003eThis product is supplied as lyophilized powder for research purposes only.\u003c\/p\u003e\n\u003cp\u003eScientific Background\u003c\/p\u003e\n\u003cp\u003eGrowth Hormone-Releasing Hormone (GHRH) is a naturally occurring hypothalamic peptide responsible for stimulating growth hormone secretion through activation of the GHRH receptor, a Class B G protein-coupled receptor expressed on pituitary somatotroph cells.\u003c\/p\u003e\n\u003cp\u003eNative GHRH exhibits a very short plasma half-life due to rapid degradation by enzymes such as dipeptidyl peptidase IV (DPP-IV) and other proteolytic mechanisms, limiting its usefulness for prolonged experimental studies.\u003c\/p\u003e\n\u003cp\u003eCJC-1295 With DAC was engineered from the biologically active GHRH(1–29) fragment and incorporates several amino acid substitutions that improve resistance to enzymatic degradation. Additionally, the peptide contains a Drug Affinity Complex (DAC) based on a maleimidopropionic acid (MPA) group that covalently binds to the free cysteine-34 residue of circulating serum albumin.\u003c\/p\u003e\n\u003cp\u003eThis albumin-binding mechanism dramatically prolongs systemic exposure and enables sustained activation of GHRH signaling pathways in experimental models.\u003c\/p\u003e\n\u003cp\u003eKey Features\u003c\/p\u003e\n\u003cp\u003eSynthetic GHRH analogue\u003c\/p\u003e\n\u003cp\u003eDrug Affinity Complex (DAC) technology\u003c\/p\u003e\n\u003cp\u003eExtended plasma half-life\u003c\/p\u003e\n\u003cp\u003eImproved metabolic stability\u003c\/p\u003e\n\u003cp\u003eLyophilized powder\u003c\/p\u003e\n\u003cp\u003e≥99% purity\u003c\/p\u003e\n\u003cp\u003eManufactured for laboratory research only\u003c\/p\u003e\n\u003cp\u003eSpecifications\u003c\/p\u003e\n\u003cp\u003eProduct Name: CJC-1295 With DAC\u003c\/p\u003e\n\u003cp\u003eContent: 5 mg\u003c\/p\u003e\n\u003cp\u003eFormat: Lyophilized Powder\u003c\/p\u003e\n\u003cp\u003ePurity: ≥99%\u003c\/p\u003e\n\u003cp\u003eStorage: Store refrigerated at 2–8°C. Protect from light and moisture.\u003c\/p\u003e\n\u003cp\u003eReconstitution: Reconstitute using bacteriostatic water or sterile water intended for laboratory research.\u003c\/p\u003e\n\u003cp\u003eResearch Grade: Laboratory Research Material\u003c\/p\u003e\n\u003cp\u003eDisclaimer\u003c\/p\u003e\n\u003cp\u003eFor Research Use Only (RUO). This product is intended exclusively for laboratory and scientific research. It is not intended for human consumption, veterinary use, diagnosis, treatment, or prevention of any disease.\u003c\/p\u003e","brand":"BY Peptides","offers":[{"title":"Default Title","offer_id":56579226894676,"sku":null,"price":44.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0926\/5928\/6356\/files\/rn-image_picker_lib_temp_8103c460-4a3f-41f7-8df0-ab550601b16e.png?v=1785170488","url":"https:\/\/bypeptides.co.uk\/products\/cjc-1295-with-dac-5mg","provider":"BY Peptides","version":"1.0","type":"link"}